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Title: Novel bridgehead nitrogen heterocyclic systems: Synthesis and antimicrobial activity of imidazo [2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles, s-triazolo[3,4-b] [1,3,4] thiadiazolo[3,2-b] imidazo [4,5-b] quinoxaline and bis-(s-triazolo [3,4-b][1,3,4]thiadiazolo[3,2-b] [imidazo[ 4,5-b]-cyclohexane]-5a, 6a-diene)
Authors: Mohan, Jag
Issue Date: Apr-2001
Publisher: NISCAIR-CSIR, India
Abstract: Condensation of 4-amino-5-mercapto-3-p-(t-butylphenyl)-s-triazole 1 with cyanogen bromide gives 6-amino-3-p-(t-butylphenyl)-s-triazolo[3,4-b][1,3,4]thiadiazole 2 which on condensation of with chloranil yields 3,9-di-p-(t-butylphenyl)-6, 14-dioxo-bis-(s-triazolo[3,4-b][1,3,4]thiadiazolo[3,2-b]-[imidazo[4,5-b]cyclohexane]-5a,6a-diene) 3. 3-p-(t-Butylpheny l)-s-triazolo[3,4-b][1,3,4]thiadiazolo[3,2-b]-imidazo [4,5-b] quinoxaline 4 is obtained by a similar condensation of 2 with 2,3-dichloroquinoxaline. The reaction of 2 with α-haloketones followed by bromination affords 7-aryl-3-p-(t-butylphenyl)imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles 5 and their 6-bromo analogues 6 respectively. The antibacterial and antifungal activities of some of the compounds have also been evaluated.
Page(s): 303-306
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(04) [April 2001]

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