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Title: Synthesis and pharmacological studies of 1-p-nitrobenzoyl-3-(3-substituted-2-hydroxypropyloximino) indole-2,3-diones
Authors: Padhy, A K
Panda, P K
Sahu, S K
Misro, P K
Issue Date: Mar-2001
Publisher: NISCAIR-CSIR, India
Abstract: Sodium salt of 3-oximino indole-2,3-dione on reaction with epichlorohydrin in N,N'-dimeth ylformamide gives 3-(2,3-epoxypropyloximino) indole-2,3-dione 2. Compound 2 on reaction with diverse secondary amines yields corresponding Mannich bases 3a-e, which on benzoylation furnish 4a-e. The synthetic benzoyl derivatives of 4a-e have been screened for their pharmacological activities.
Page(s): 258-261
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(03) [March 2001]

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