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Title: Synthesis and anti-cancer activity of pyridine and thiazolopyrimidine derivatives using 1-ethylpiperidone as a synthon
Authors: Hammam, Abou El-Fotooh G
Sharaf, Mohie A
El-Hafez, Naglaa A Abd
Issue Date: Mar-2001
Publisher: NISCAIR-CSIR, India
Abstract: 3,5-Bisarylmethylene-1-ethylpiperidone 2 on reaction with thiourea yield the thioxopyri midine derivatives 3, which on condensation with bromoacetic acid, 2-bromopropanoic acid or 3-bromopropanoic acid afford thiazolopyrimidine 4, 2-methyl-thiazolopyrimidines 5 and thiazinopyrimidine derivatives 6, respectively. Compounds 7 and 8 are also obtained via condensation of compounds 3 with 3-chloropentan-2, 4-dione, bromoacetic acid and aromatic aldehydes, respectively. However, compounds 8 are prepared directly by condensation of compounds 4 with aromatic aldehydes. Compounds 2 on condensation with malononitrile in ethanol/piperidine or acetic acid/ammonium acetate mixture give pyridopyran 9 and pyridopyridine 10, respectively. Also compound 10 could be prepared directly from compound 9. Compounds 2 when condensed with phenylhydrazine, ethyl cyanoacetate or guanidine hydrochloride yields pyridopyrazole 11, pyridopyridone 12 and pyridoaminopyrimidine derivatives 13, respectively.
Page(s): 213-221
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(03) [March 2001]

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