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Title: Development of quality control markers for Ulmus wallichiana Planchon: An Indian traditional plant for osteogenic activity
Authors: Arya, K R
Khatoon, Sayyada
Kumar, Brijesh
Keywords: Ulmus wallichiana;Bone healing;Q TOF HRMS;Quality control marker;HPTLC
Issue Date: Oct-2013
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A01D 20/00, A01D 9/02, G07C 3/14, A62B
Abstract: Ulmus wallichiana Planchon, is an Indian folk traditional plant used for the treatment of fractured bones in folklore tradition of Uttarakhand Himalaya, India. During chemical investigations, three major compounds, Ulmoside A & B, and Naringenin-6-C-β-D glucopyranosideis for osteogenic activity have been isolated from bark of this plant species. This paper presents macro and microscopic study, physicochemical parameters and chemo-profiling of stem bark of U. wallichiana through Q TOF HRMS for development of quality control markers and identification of crude samples. Transverse section (TS) stem bark and powder microscopy shows crushed rhytidoma consisting plenty of mucilaginous canals followed by crushed cork, cells of the cork filled with dark brown content. Whereas, authenticity and quality of raw materials can be determinate with exact calculated mass value of marker compounds for osteogenic activity at 467, 451 and 435 using Q TOF HRMS technique. Ursolic acid, β-sitosterol and lupeol at Rf value 0.25, 0.36 and 0.44 has also identified as HPTLC marker for identification and authentication of crude drug samples of stem bark of U. wallichiana.
Page(s): 664-669
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.12(4) [October 2013]

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