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Title: Synthesis and fungitoxicity of fluorinated-1,2,4-triazolo-and thiadiazolo[3 ,2-b]-1,3,4 oxadiazoles
Authors: Singh, Harendra
Srivastava, Manoj Kumar
Singh, Brij Kishore
Singh, Sanjay Kumar
Dubey, Garima
Issue Date: Feb-2001
Publisher: NISCAIR-CSIR, India
Abstract: 2-Amino-5- aryl-1,3,4-oxadiazole undergoes regioselective condensation with KSC to give (5-aryl-1,3,4-oxadiazolyl)-thioureas 2a-c and with aryl isothiocyanates to give N-phenyl-N'-(5-aryl-1,3,4-oxadiazol-2-yl)-thioureas 2d-i, in methanol. The ureas 2 on treatment with ethanol and iodine (till the decolourisation of iodine) yield 4. The compounds have been tested in vitro for their fungicidal activity against Cephalosporium saccharii, Aspergillus niger and Fusarium oxysporium and the results are compared with their parent thioureas. The structural features of the tested compounds have been correlated with their fungicidal activity.
Page(s): 159-162
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(02) [February 2001]

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