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Title: Zinc promoted rapid and efficient synthesis of Fmoc- and Z-α, α-dialkylamino acids under neutral conditions
Authors: Babu, Vommina V. Suresh
Ananda, Kuppanna
Issue Date: Jan-2001
Publisher: NISCAIR-CSIR, India
Abstract: The introduction of Nα-9-fluorenylmethyloxycarbonyl (Fmoc) and benzyloxycarbonyl (Z) groups into α, α-dialkylamino acids is described at neutral pH using Fmoc-Cl or Z-Cl as an acylating agent respectively in the presence of activated zinc powder. The reaction is simple, fast and clean. It also permits the scale up with high yields. It is completely free from protected oligomer formation, which is a known side-reaction when Schotten Baumann procedure is followed. All the Fmoc- and Z-amino acids prepared have been fully characterized.
Page(s): 70-74
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(01) [January 2001]

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