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|Title:||Synthesis of some new thiouracil derivatives with expected biological activity|
|Authors:||Fathalla, O A|
|Abstract:||Simple synthesis of 5-substituted thiouracil has been achieved by the chlorosulphonation to give 2-thiouracil-5-sulphonylchloride 2 which then heated with primary amines to give the amides 3a-c. Compound 2 on treatment with p-amino-acetophenone and p-hydroxyacetophenone furnishes respectively 4 and 5 while with hydrazine 6 is obtained. Compound 2 on reaction with secondary amines namely morpheline, N-methylpiperazine and diethylamine respectively furnishes 12a-c.All the compounds have been characterized by IR and NMR spectra.|
|Appears in Collections:||IJC-B Vol.40B(01) [January 2001]|
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