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Title: Synthesis of some new thiouracil derivatives with expected biological activity
Authors: Fathalla, O A
Issue Date: Jan-2001
Publisher: NISCAIR-CSIR, India
Abstract: Simple synthesis of 5-substituted thiouracil has been achieved by the chlorosulphonation to give 2-thiouracil-5-sulphonylchloride 2 which then heated with primary amines to give the amides 3a-c. Compound 2 on treatment with p-amino-acetophenone and p-hydroxyacetophenone furnishes respectively 4 and 5 while with hydrazine 6 is obtained. Compound 2 on reaction with secondary amines namely morpheline, N-methylpiperazine and diethylamine respectively furnishes 12a-c.All the compounds have been characterized by IR and NMR spectra.
Page(s): 37-42
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(01) [January 2001]

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