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Title: One pot synthesis of some new biologically active arylfurylthiadiazolotriazinones
Authors: Holla, B Shivarama
Shivananda, M K
Veerendra, B
Issue Date: Dec-2002
Publisher: NISCAIR-CSIR, India
Abstract: 4-Amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 1 are condensed with 5-aryl-2-furoic acids 2 to yield 7-(5-aryl-2-furyl)-3-arylmethyl-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4(H)-ones 3 employing phosphorus oxychloride as a cyclizing agent in one pot synthesis. Similarly, 7 -(5-aryl-2-furyl)-3-(t-butyl)-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4(H)-ones 5 have been synthesized. All the newly synthesized thiadiazolotriazinones 3 and 5 have been tested for their antibacterial activities against E.coli, S.aureus, P.aeruginosa and B.subtilis and their MIC values are determined. Compounds 3a-c have been found to be promising antibacterial agents.
Page(s): 2690-2693
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(12) December 2002]

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