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Title: Synthesis of some newer indolyl-thiadiazolyl-pyrazolines and indolyl-oxadiazolyl-pyrazolines as potential anti-inflammatory agents
Authors: Sharma, Shalabh
Srivastava, Virendra Kishor
Kumar, Ashok
Issue Date: Dec-2002
Publisher: NISCAIR-CSIR, India
Abstract: Some new l-acetyl-5-substitutedaryl-3-[5 '-(3"-indolylmethyl)-2'-amino-1',3',4'-thiadiazol-2' N-yl]-2-pyrazolines 6a-6c and 1-acetyl-5-substitutedaryl-3-[5'-(3"-indolylmethyl)-2'-amino-1' ,3' ,4'-oxadiazol-2' N-yl]-2-pyrazolines 6'a-6'e have been synthesized by 5-(3'-indolymethyl)- 1,3,4-thiadiazolyl-2-aminosubstitutedchalkones 5a-5e and 5-(3'-indolylmethyl)-1,3,4-oxadiazolyl-2-aminosubstitutedchalkones 5'a-5'e, respectively. All these compounds of the present series have been screened for their anti-inflammatory activity. Compounds 6c and 6'c are found to be most active compound of this series, which show 47.6% and 49.0% inflammation inhibitory activity at a dose of 50 mg/kg p.o., while standard drug phenylbutazone exhibit 45.6% anti-inflammatory activity at same dose. The structure of these compounds has been illustrated by IR and 1H NMR spectra.
Page(s): 2647-2654
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(12) December 2002]

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