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Title: Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones
Authors: Rani, Preeti
Srivastava, V K
Kumar, Ashok
Issue Date: Dec-2002
Publisher: NISCAIR-CSIR, India
Abstract: Some new quinazolinone derivatives, 3-(substituted phenyl)-2-(substituted phenylchalconylaminoazetidinon-2'-yl)-6- monosubstitutedquinazolin-4(3H)-ones have been synthesized by the reaction of 3-(substituted phenyl)-2-(substituted phenylchalconylhydra zinomethyl)-6-monosubstituted-quinazolin-4(3H)-ones with acetyl chloride in the presence of triethylamine. All the compounds or this series have been evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. The activity of the most active member of this series i.e. 3-(o-methoxyphenyl)-2-(p-dimethylaminophenylchal conylaminoazetidinon-2'-yl) quinazolin-4(3H)-one has been studied in detial and is compared with phenylbutazone. Interestingly this compound exhibits better anti -inflammatory activity and lower ulcerogenic liability than phenylbutazone and its toxicity is also quite low.
Page(s): 2642-2646
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(12) December 2002]

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