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Title: Synthesis of potential quinazolinonyl pyrazolines and quinazolinyl isoxazolines as anticonv ulsant agents
Authors: Archana
Srivastava, V K
Chandra, Ramesh
Kumar, Ashok
Issue Date: Nov-2002
Publisher: NISCAIR-CSIR, India
Abstract: A series of 1-[3'-amino-2'-methyl-6'-monosubstitutedquinazolin-4'(3'H)-onyl]-3-(arylideny l)chalcones 3 have been synthesized via condensation of 3-acctylamino-2-methyl-6-monosubstitutedquinazolin-4(3H)-ones 2 with various aromatic aldehydes. Cycloaddition of hydrazine hydrate with 3 yields 1-acetyl-5-substitutedaryl-3-(3’-amino-2'-methyl-6'monosubstitutedquinazolin-4'(3'H)-onyl]-2-pyrazolines 4 and cyclocondensation of hydroxylamine hydrochloride with 3 affords 5-substitutedaryl-3- [3'-amino-2'-methyl-6'-monosubstitutedquinazolin-4' -(3'H)-onyl]-isoxazolines 5. Compound 4g and 5g show most potent activity (90%) more potent than standard drug phenytoin sodium (80%).
Page(s): 2371-2375
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(11) [November 2002]

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