Please use this identifier to cite or link to this item:
|Title:||Synthesis and blood pressure lowering activity of some newer quinazolinones|
Srivastava, V K
|Abstract:||Some new 3-[3'-(aminoacetylthiosemicarbazido)-4'-oxo-2'-(substituted-aryl)-1'-thiazolidinyl] -2-methylmonosubstituted-quinazolin-4(3H)-ones 5a-j have been synthesized by 1,5 cyclocondensation of thioglycolic acid with 3-(aminoacetylthiosemicarbazidosubsti tutedarylidene)-2-methylmono-substitutedquinazolin-4(3H)ones 4a-j. All the newly synthesized compounds of the series have been evaluated for their hypotensive activity. The most active compound of the series is 3-[1'-(aminoacetylthiosemicarbazido)-4'-oxo-5'-(4-hydroxy ,3-methoxyphenyl)-1'-thiazolidinyl]-2-methyl-6-bromoquinazolin-4(3H)-one 5h, which has shown blood pressure lowering activity of 83 mmHg at a dose of 2.5 mg/kg i.v. The structures of all these compounds have been delineated by elemental analysis and spectral studies (IR and 1H NMR).|
|Appears in Collections:||IJC-B Vol.41B(11) [November 2002]|
Files in This Item:
|IJCB 41B(11) 2367-2370.pdf||863.42 kB||Adobe PDF||View/Open|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.