Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/22097
Title: Condensed bridgehead nitrogen heterocyclic systems: Synthesis and bioactivity of 2,3-dihydrothiazolo[3 ',2' :2,3]-as-triazino[5,6-b] indole, 2,3-dihydro-4H[1,3]thiazino [3',2' : 2,3]-as-triazino[5,6-b]indole and quinoxalino[2',3' :4,5]thiazolo[3,2-b]indolo[2,3-e]-as-triazine and their isomeric systems
Authors: Mohan, Jag
Kumar, Ashok
Issue Date: Nov-2002
Publisher: NISCAIR-CSIR, India
Abstract: 2,3-Dihydro-8-isopropyl-5H-as-triazino[5,6-b]indole-3-thione 2 on condensation with 1,2-dibromoethane, 1-3-dibromopropane and 2,3-dichloroquinoxaline gives the cyclized products, 7- isopropyl-2,3-dihydrothiazolo[3',2':2 ,3]-as-triazino[5,6-b] indole 3, 2,3-dihydro-8-isopropyl-4H-[1,3]thiazino[3',2':2,3]-as-triazino[5,6-b]indole 4 and 9-isopropylquinoxalino [2' ,3' :4,5]thiazolo[3,2-b] indolo[2 ,3-e]-as-triazine 5, respectively and not the angular isomers, 7-isopropyl-2,3-dihydro[2' ,3':3,4]-as-triazino[5,6-b] indole 6, 8-isopropyl-1H-2,3-dihydro[1,3]thiazino[2',3' :3,4]-as-triazino[5,6-b] indole 7 and 3-isopropylquinoxalino [2',3':4,5]thiazolo[2,3-c] indolo[2,3-e]-as- triazine 8. The unequivocal synthesis of the latter 6, 7 and 8 has been accomplished by reaction of 5-isopropylisatin-3-thiosemicarbazone 1 with 1,2-dibromoethane, 1,3-dibromopropane and 2,3-dichloroquinoxaline, respectively. The bioactivity of the synthesized compounds have also been evaluated.
Page(s): 2364-2366
URI: http://hdl.handle.net/123456789/22097
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(11) [November 2002]

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