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Title: Synthesis of novel quinoxaline carboxylic acid derivatives for antimicrobial investigation
Authors: El-Gaby, M S A
Ismail, M M F
Ammar, Y A
Zahran, M A
Shmeiss, N A M M
Issue Date: Jul-2002
Publisher: NISCAIR-CSIR, India
Abstract: 6,7-Dimethylquinoxaline-2,3-dicarboxylic acid anhydride 1 on treatment with binucleophiles 2 in ethanol at reflux condition affords 2-carboxamidoquinoxaline-3-carboxylic acid derivatives 3a-e. The biscarboxamido derivatives 4a,b are obtained upon treatment of 3a,b with the anhydride derivative 1 which are converted into the corresponding bispyrrolo derivatives 5a,b. Acetylation of 3a,b with acetic anhydride at room temperature yields the acetamido derivatives 6a,b.While, 3a,b on refluxing with acetic anhydride, afford the pyrrolo[3,4-d]quinoxaline derivatives 7a,b. The pyrrole ring in compounds 7a,b is opened via their reaction with the aromatic amines under fusion condition. Condensation of compound 3a with aromatic aldehydes in DMF furnishes the Schiffs bases 9a,b.While, on repeating the reaction under fusion condition caused decarboxylation to give the corresponding Schiffs bases 10a,b. Some of the prepared compounds are tested in vitro for their antimicrobial activities.
Page(s): 1480-1485
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(07) [July 2002]

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