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Title: Photolabile groups for exocyclic amino and O6/N-1 lactam protection in oligonucleotide synthesis
Authors: Misra, Arvind
Tripathi, Snehlata
Misra, Krishna
Issue Date: Jul-2002
Publisher: NISCAIR-CSIR, India
Abstract: The use of o-nitrobenzyloxycarbonyl (nCbz) for direct protection of exocyclic amino function of nucleosides viz.adenosine, cytidine and deoxyguanosine using o-nitrobenzyl-p-nitrophenyl carbonate as a reagent and O6-derivatization of deoxyguanosine with o-nitrobenzyl (nBzl) using o-nitrobenzyldiazomethane as a reagent is being reported. Both these protected groups could be cleaved by irradiation at 354nm to yield valuable building blocks for oligonucleotide synthesis.
Page(s): 1454-1459
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(07) [July 2002]

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