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|Title:||Photolabile groups for exocyclic amino and O6/N-1 lactam protection in oligonucleotide synthesis|
|Abstract:||The use of o-nitrobenzyloxycarbonyl (nCbz) for direct protection of exocyclic amino function of nucleosides viz.adenosine, cytidine and deoxyguanosine using o-nitrobenzyl-p-nitrophenyl carbonate as a reagent and O6-derivatization of deoxyguanosine with o-nitrobenzyl (nBzl) using o-nitrobenzyldiazomethane as a reagent is being reported. Both these protected groups could be cleaved by irradiation at 354nm to yield valuable building blocks for oligonucleotide synthesis.|
|Appears in Collections:||IJC-B Vol.41B(07) [July 2002]|
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