Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21934
Title: Syntheses, characterisation and fluorescence study of some novel naphthalimide derivatives
Authors: Singh, Yashveer
Misra, Arvind
Misra, Krishna
Issue Date: Jun-2002
Publisher: NISCAIR-CSIR, India
Abstract: Three fluorescent derivatives viz. 4-tosylamido-1,8-naphthalic anhydride, 4-dansylamido-1,8-naphthalimido-N-pentanol and 4-dabsylamido-1,8-naphthalimido-N-pentanol have been prepared and characterised. The comparative fluorescence studies and quantum yield estimation has been carried out in different solvents such as methanol, dioxane, water, water-methanol gradient, normal aqueous solutions of sodium carbonate, hydrochloric acid and buffers like ammonium acetate, 1X TRIS-EDTA and the effect of inorganic salts like sodium chloride, potassium chloride, magnesium sulphate has also been studied. Thus, optimal conditions for maximum fluorescence yield has been worked out. The fluorescent derivatives reported herein have the potential to be used for covalent as well as non-covalent labelling of various biomolecules, specially to synthetic oligonucleotides. The labelled oligonucleotides have been proved to be of immense value as probes in clinical diagnostics.
Page(s): 1238-1245
URI: http://hdl.handle.net/123456789/21934
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(06) [June 2002]

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