Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21913
Title: Coupling in the absence of a tertiary base: A method for the deprotonation of hydrochloride salts of peptide esters to free amino peptide esters
Authors: Tantry, Subramanyam J
Ananda, K
Babu, V V Suresh
Issue Date: May-2002
Publisher: NISCAIR-CSIR, India
Abstract: The deprotonation of hydrochloride salts of peptide esters is accomplished using activated zinc dust. The reaction is neat and quantitative. Addition of a tertiary base is eliminated during the coupling. The free amino peptide esters have been isolated in good yield and purity. This method is extended for the synthesis of β-casomorphin (Tyr-Pro-Phe-Pro-Gly). During its synthesis, all the intermediate free amino peptide esters have been isolated and characterized.
Page(s): 1028-1031
URI: http://hdl.handle.net/123456789/21913
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(05) [May 2002]

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