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Title: Condensed bridgehead nitrogen heterocyclic systems:Synthesis and antimicrobial activity of thiazolo[3', 2': 2, 3]-as-triazino[5,6-b]indoles and isomeric thiazolo[2', 3': 3,4]-as-triazino[5, 6-b]indoles
Authors: Mohan, Jag
Issue Date: Mar-2002
Publisher: NISCAIR-CSIR, India
Abstract: 2, 3-Dihydro-6-ethyl-5H-as-triazino[5, 6-b]indole-3-thione 4 on condensation with α-haloketone gives 3-aroylmethylthio-6-ethyl-5H-as-triazino[5, 6-b]indolehydrobromide 5 which on PPA catalyzed cyclization furnishes 3-aryl-9-ethylthiazalo[3', 2': 2, 3]-as-triazino[5, 6-b]indole 6 and not the isomer, 1-aryl-9-ethylthiazalo[2', 3': 3,4]-as-triazino[5, 6-b]indole 8. The unequivocal synthesis of 8 has also been accomplished. The antibacterial and antifungal activity of the compound 6 has also been evaluated.  
Page(s): 628-630
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(03) [March 2002]

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