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Title: Determination of pKa’s of hydroxamic acids by nucleophilic substitution reaction
Authors: Shrivastava, Ashish
Ghosh, Kallol K
Issue Date: Oct-2007
Publisher: CSIR
Abstract: Acid dissociation constant (pKa) of some para-substituted benzohydroxamic, 4-XC₆H₄CONHOH, and N-methyl para-substituted benzohydroxamic acids, 4- XC₆H₄CON(OH)CH₃, where X = H, CH₃, CH₃O, NO₂, Cl, have been determined spectrophotometrically by nucleophilic substitution reactions of p-nitrophenyl acetate with hydroxamate ions at 27± 0.1ºC. All reactions in this study follow pseudo-first order kinetics under condition of excess nucleophile. Good correlation has been observed between pKa and substitutent constants pointing out the validity of the Hammett equation. The kinetics results have been discussed on the basis of pKa and ⍺-effect of hydroxamic acids.
Page(s): 1630-1634
ISSN: 0376-4710
Appears in Collections:IJC-A Vol.46A(10) [October 2007]

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