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Title: Ionic liquid mediated synthesis of some novel fluoro isoxazolidine and isoxazoline derivatives using N-benzyl fluoro nitrone via cycloaddition reaction and their antimicrobial activities
Authors: Chakraborty, Bhaskar
Samanta, Amalesh
Luitel, Govinda Prasad
Khatun, Nasima
Keywords: N-Benzyl fluoro nitrone;Cycloaddition reaction;Fluoro isoxazolidine;Fluoro isoxazolines;Ionic liquid;1,3-amino alcohol;Aldehyde/ketone synthesis;Antimicrobial activity
Issue Date: Oct-2013
Publisher: NISCAIR-CSIR, India
Abstract: 1-Butyl-3-methylimidazolium based ionic liquids are found to accelerate significantly the intermolecular 1,3-dipolar cycloaddition of N-benzyl-fluoro nitrone derived in situ from 2,6-difluoro benzaldehyde and N-benzylhydroxylamine, with activated alkenes and electron deficient alkynes to afford enhanced rates and improved yields of isoxazolidine, isoxazolines. All the novel isoxazolidine and isoxazoline derivatives have been screened for antimicrobial activities and found to be very active.
Page(s): 1342-1351
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(10) [October 2013]

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