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Title: Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and antimicrobial activity of spiro[cycloalkane-1', 7(8H)-(6H)-trans-3, 3a-dihydropyrazolo[3', 4':4,5] thiazolo[3, 2-b]-s-tetrazines]
Authors: Mohan, Jag
Kumar, Ashok
Khatter, Diksha
Issue Date: Feb-2002
Publisher: NISCAIR-CSIR, India
Abstract: A facile synthesis of trans-3, 3a-dihydro-3-arylspiro[cycloalkane-1', 7(8H)[6H]pyrazolo[3', 4':4, 5]thiazolo[3, 2-b]-s-tetrazines 3 has been achieved by the condensation of 1, 2, 4, 5-tetraazaspiro[5, 7]tridecane-3-thione 1a or 1, 2, 4, 5-tetraazaspiro [5, 6] dodecane-3-thione 1b or 1, 2, 4, 5-tetraazaspiro[5, 5]undecane-3-thione 1c with ethyl chloroacetate and aldehydes in the presence of pyridine and piperidine to yield 7-arylidene-6(7H)-oxospiro[cyclooctane/ cycloheptane/ cyclohexane]-1, 3 (4H)-[2H] thiazolo [3, 2-b]-s-tetrazines 2 followed by treatment with p-nitrophenylhydrazine. The antibacterial and antifungal activity of some of the compounds have also been evaluated.
Page(s): 400-402
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(02) [February 2002]

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