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Title: An unexpected synthesis of 1H perimidin — X-ray crystal structure of 1H-perimidine hydrochloride dihydrate
Authors: Ng, Seik W
Drew, Michael G B
Mostafa, Golam
Patra, Goutam K
Datta, Dipankar
Issue Date: Jan-2002
Publisher: NISCAIR-CSIR, India
Abstract: Action of HCl on 1-(8'-amino-α-naphthyl)-4-(8'-amino-anaphthylamine)-1-azabuta-1 ,3-diene in aqueous methanol yields the mono hydrochloric acid salt of 1H-perimidine 1 as a dihydrate. A tentative mechanism for the reaction is proposed. The X-ray crystal structure of the salt has been determined. Neutralisation of an aqueous solution of the hydrochloride salt by a base generates 1, which has antitumor activities, in the free state.
Page(s): 211-214
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(01) [January 2002]

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