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Title: Synthesis and antibacterial properties of nitrofuryltriazolothiadiazepines
Authors: Holla, B Shivarama
Shridhara, K
Shivanandaa, M K
Issue Date: Dec-2003
Publisher: NISCAIR-CSIR, India
Abstract: Methyl aryl ketones 1 on reaction with 5-nitrofurfuraldehyde 2 give l-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 3 which on bromination affords 2,3-dibromo-1-aryl-3-(5-nitro-2-furyl )-2-propen-1-ones 4. Debromination of 4 by triethylamine in benzene results in 1-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 5 which on condensation with 3-substituted-4-amino-5-mercapto-1,2,4-triazole 6 furnishes Michael adducts 7. The Michael adduct 7 undergoes cyclization in conc. sulphuric acid to give 3-aryloxymethyl-6-aryl-8-(5-nitro-2-furyl)-1,2,4-triazolothiadiazepines 8. Antibacterial activity of 7 and 8 has been reported.
Page(s): 3113-3116
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(12) December 2003]

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