Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21739
Title: Synthesis of new biologically active arylfuranylmethyltriazinones and their antibacterial activity studies+
Authors: Holla, B Shivarama
Shivananda, M K
Veerendra, B
Bhat, K Subrahmanya
Issue Date: Oct-2003
Publisher: NISCAIR-CSIR, India
Abstract: In view of the pharmacological activities of 1,2,4-triazinones, a series of 4-amino-6-arylfurany lmcthyl-3-mercapto- 1 ,2,4- triazin-5(4H)-ones 7 have been synthesized by refluxing pyruvic acids 5 in ethanol with thiocarbohydrazide 6 on a steam-bath. The structures of 7 are confirmed by elemental analysis, IR, NMR and mass spectral data. Also, these compounds 7 have been screened for antibacterial activities against E. coli, S.aureus, P. aeruginosa and G.bacillus. Their MIC values are determined. The results indicate that among the compounds tested, compounds 7a and 7c carrying p-chloro and p-bromo substituents show excellent anti bacterial activity against all the bacteria tested. It is concluded that compounds 7a, 7c, 7d and 7f may prove to be promising antibacterial agents.
Page(s): 2649-2651
URI: http://hdl.handle.net/123456789/21739
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(10) [October 2003]

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