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Title: Synthesis of thiadiazolo-s-triazines for their antiviral activity based on QSAR studies
Authors: Pandey, V K
Tusi, Z
Tandon, M
Joshi, M N
Bajpai, S K
Issue Date: Oct-2003
Publisher: NISCAIR-CSIR, India
Abstract: 2-Amino-5-aralkyl-1,3,4-thiadiazole 1 on treatment with benzaldehyde yields 5-aralkyl-2-benzylideno-imino-1,3,4-thiadiazole 2 which on reaction with ammonium thiocyanate cyclises to give 2-phenyl-7-aralkyl-1 ,3,4-thiadiazolo-[3,2-a]-s-triazine-5- [6H,7 H]-thione 3. Reaction of 3 with p-toluene sulphonyl chloride in anhydrous chloroform gives 2-phenyl-3-(p-toluenesulphonyl)-7-aralkyl-1,3,4-thiadiazolo-[3,2-a]-s-triazine-5-[6H, 7H]-thiones 4g-1. Benzoyl chloride also reacts with 3 in anhydrous pyridine giving 2-phenyl-3-(benzoyl)-7-aralkyl-1,3,4-thiadiazolo-[3,2-a]-s-triazine-5-[6H,7 H]-thiones 4a-f in quantitative yields. The antiviral activities of 4 based on QSAR studies have been reported using physicochemical method.
Page(s): 2583-2588
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(10) [October 2003]

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