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http://nopr.niscair.res.in/handle/123456789/21722| Title: | Synthesis of thiadiazolo-s-triazines for their antiviral activity based on QSAR studies |
| Authors: | Pandey, V K Tusi, Z Tandon, M Joshi, M N Bajpai, S K |
| Issue Date: | Oct-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Amino-5-aralkyl-1,3,4-thiadiazole 1 on treatment with benzaldehyde yields 5-aralkyl-2-benzylideno-imino-1,3,4-thiadiazole 2 which on reaction with ammonium thiocyanate cyclises to give 2-phenyl-7-aralkyl-1 ,3,4-thiadiazolo-[3,2-a]-s-triazine-5- [6H,7 H]-thione 3. Reaction of 3 with p-toluene sulphonyl chloride in anhydrous chloroform gives 2-phenyl-3-(p-toluenesulphonyl)-7-aralkyl-1,3,4-thiadiazolo-[3,2-a]-s-triazine-5-[6H, 7H]-thiones 4g-1. Benzoyl chloride also reacts with 3 in anhydrous pyridine giving 2-phenyl-3-(benzoyl)-7-aralkyl-1,3,4-thiadiazolo-[3,2-a]-s-triazine-5-[6H,7 H]-thiones 4a-f in quantitative yields. The antiviral activities of 4 based on QSAR studies have been reported using physicochemical method. |
| Page(s): | 2583-2588 |
| URI: | http://hdl.handle.net/123456789/21722 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(10) [October 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(10) 2583-2588.pdf | 915.16 kB | Adobe PDF | View/Open |
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