Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21714
Title: Synthetic approaches towards 3-pyridinecarbonitrile derivatives and their antimicrobial properties
Authors: Kamel, Mona M
Hussein, Manal M M
Issue Date: Sep-2003
Publisher: NISCAIR-CSIR, India
Abstract: A variety of 2-alkoxy-4,6-diaryl-3-pyridinecarbonitriles 2 have been prepared via either the reaction of 1,3-diaryl-2-propen-1-ones 1 with malononitrile or the reaction of ylidenemalononitriles 6 with the proper aryl methyl ketone 7 in the appropriate alcohol in the presence of sodium. On the other hand, conducting the reaction in refluxing ethanol in the presence of ammonium acetate affords, the corresponding 2-amino-3-pyridinecarbonitriles 8. The antimicrobial properties against Gram-positive, Gram-negative, acid-fast bacteria and yeast have been screened. The prepared propenones 1a-d show considerable activity against the tested yeast as well as most of the Gram-positive and Gram-negative bacteria. A few derivatives of the prepared pyridines 2c,f,h ; 8b exhibit mild antimicrobial activity.
Page(s): 2136-2141
URI: http://hdl.handle.net/123456789/21714
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(09) [September 2003]

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