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Title: Synthesis of β-casomorphin employing Fmoc-amino acid chlorides and t- butyldimethylsilyloxy benzotriazole (TBDMS-OBt)
Authors: Tantry, Subramanyam J
Mathad, Raveendra I
Babu, Vommina V Suresh
Issue Date: Sep-2003
Publisher: NISCAIR-CSIR, India
Abstract: Coupling of Fmoc-amino acid chlorides can be carried out using t-butyldimethylsilyloxy benzotriazole, the reaction being carried out in organic medium. No addition of base is required. The coupling is fast and racemization free. The workup and isolation of product are easy. Thus, the synthesis of β-casomorphin (Tyr-Pro-Phe-Pro-Gly) is accomplished.
Page(s): 2104-2108
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(09) [September 2003]

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