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|Title:||Synthesis and evaluation of antiinflammatory and analgesic activity of some new 1,3-diphenyl-2-aryltetrahydroimidazoles|
|Authors:||Khan, M S Y|
|Abstract:||In an effort to search for new antiinflammatory and analgesic agents, some new tetrahydroimidazole derivatives 2a-2g have been synthesized via condensation of 1,2-dianilinoethane with various aldehydes. Characterization of the newly synthesized compounds has been done on the basis of 1H NMR and mass spectral data. The resulting compounds have been evaluated for their antiinflammatory activity. The activity of compounds 2b and 2c is excellent and comparable to indomethacin. All these compounds have been tested for their analgesic activity also and their LD50 determined. Compounds 2b and 2c show a comparable activity with aspirin. The MTD for all the compounds is found to be > 1800 mg/kg.|
|Appears in Collections:||IJC-B Vol.42B(09) [September 2003]|
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