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Title: Synthesis of some 4-(arylmethylamino)-4, 5-dihydro-1H-1 ,2,4-triazol-5-ones
Authors: Kahveci, Bahittin
Bekircan, Olcay
Serdar, Mevlut
Ikizler, A Aykut
Issue Date: Jun-2003
Publisher: NISCAIR-CSIR, India
Abstract: A series of 3-alkyl-4-(arylmethyleneamino)-4,5-dihydro-1 H-1,2,4-triazol-5-ones 2 are obtained and reduced with NaBH4 selectively to afford 3-alkyl-4-(arylmethylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3. Compounds of type 2 have recently described as a new class of antitumor agent. Thus, 15 new compounds have been synthesized and characterized by elemental analyses, 1H NMR, IR and UV spectra. Three of these compounds have been screened for their antitumor activities and found weak cytostatic activity in them.
Page(s): 1527-1530
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(06) [June 2003]

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