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Title: Synthesis, anticancer, antitubercular and antimicrobial activity of 6-carbethoxy-5-(3' chlorophenyl)-3-aryl-2-cyclohexenones and 6-aryl-4-(3'-chlorophenyl)-3-oxo-2,3a,4,5-tetrahydro-1H-indazoles
Authors: Popat, K H
Nimavat, K S
Vasoya, S L
Joshi, H S
Issue Date: Jun-2003
Publisher: NISCAIR-CSIR, India
Abstract: 6-Carbethoxy-5-(3'-chlorophenyl)-3-aryl-2-cyclohexenones 2a-j are obtained from the chalcones 1a-j by Micheal addition of ethyl acetoacetate, followed by internal Claisen condensation. Reaction of 2a-j with hydrazine hydrate affords the corresponding 6-aryl-4-(3' -chlorophenyl)-3-oxo-2, 3a-4,5-tetrahydro-1H-indazoles 3a-j. The synthesized compounds have been evaluated for their anticancer, antitubercular and antimicrobial activity.
Page(s): 1497-1501
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(06) [June 2003]

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