Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21613
Title: Condensed heterocyclic systems containing bridgehead nitrogen atom:Synthesis and bioactivity of imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles, s-triazolo-[3,4-b]-1 ,3,4-thiadiazolo[3,2-b]imidazo[4,5-b] quinoxaline and bis(s-triazolo[3,4-b]-1 ,3,4-thiadiazolo[3,2-b] [imidazo[4,5-b]cyclohexane]-5a,6a-diene)
Authors: Mohan, Jag
Kumar, Ashok
Issue Date: Jun-2003
Publisher: NISCAIR-CSIR, India
Abstract: Condensation of 4-amino-5-mercapto-3-(m-methylphenyl)-s-triazole 1 with cyanogen bromide gives 6-amino-3-(m-methylphenyl)-s-triazolo[3,4-b]-1,3,4-thiadiazole 2 which on condensation with chloranil yields 3,9-di (m-methylphenyl)-6,14-dioxo-bis-(s-triazolo[3,4-b ]- 1,3,4-thiadiazolo[3,2-b][imidazo[4,5-b] cyclohexane]-5a, 6a-diene) 3. 3-(m-methylphenyl)-s-triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b] imidazo[4,5-b]quinoxaline 4 is obtained by a similar condensation of 2 with 2,3-dichloroquinoxaline. The reaction of 2 with α-haloketones followed by bromination affords 7-aryl-3-(m-methylphenyl) imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles 5 and their 6-bromo analogues 6 respectively. The antibacterial and antifungal activities of some of the compounds have also been evaluated.
Page(s): 1463-1466
URI: http://hdl.handle.net/123456789/21613
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(06) [June 2003]

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