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Title: 2-Methoxy-5-methylphenyl thiosemicarbazide: A versatile molecule for the synthesis of thiadiazoles and imidazolinones possessing multiple biological activities
Authors: Hirpara, S B
Parikh, K A
Merja, B C
Parekh, H H
Issue Date: May-2003
Publisher: NISCAIR-CSIR, India
Abstract: Thiosemicarbazide 1 has been prepared by the reaction of 2-methoxy-5-methyl aniline, ammonia and carbon disulphide with ethanol (95%) and sodium chloroacetate, followed by addition of hydrazine hydrate, which on cyclisation with different aromatic carboxylic acids and substituted azlactones in pyridine furnish the corresponding 2-aryl-5-(2 '-methoxy-5'-methylphenyl amino)- 1,3,4-thiadiazoles 2a-o and 2-phenyl- 4-arylidene-1-(2'-methoxy- 5'-methylphenyl thiourido)-5-oxo-imidazolines 3a-o. All the compounds have been characterised by elemental analyses, IR, 1H NMR and Mass spectral data. All the compounds have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37Rv and anticancer activity. Two compounds are found to be active in anticancer assay.
Page(s): 1172-1175
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(05) [May 2003]

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