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|Title:||Synthesis of 6-aryl-2-(2-phenyl-1,8-naphthyridine-3-carbonyl)-4,5-dihydropyridazin- 3(2H)-ones|
|Abstract:||Condensation of 2-phenyl-1,8-naphthyridine-3-carboxylic acid hydrazide 1 with β-aroylpropionic acids 2 in ethanol affords the corresponding N-(2-phenyl-1,8-naphthyridine-3-carbonyl)-β-aroylpropionic acid hydrazones 3, which on treatment with gl. acetic acid undergo facile cyclization to yield 6-aryl-2-(2-phenyl 1,8-naphthyridine 3-carbonyl)-4,5-di hydro-pyridazin-3(2H)-ones 4. The compounds 4 have been tested for their antibacterial activity. The structures of the products have been delineated by elemental analyses and spectral studies.|
|Appears in Collections:||IJC-B Vol.42B(03) [March 2003]|
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