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Title: A novel approach to the synthesis of the purine anti-viral agent gancyclovir
Authors: Sariri, Reyhaneh
Khalili, Gholamhosein
Issue Date: Mar-2003
Publisher: NISCAIR-CSIR, India
Abstract: The aim of this research is to synthesize gancyclovir, a purine anti-viral drug in large scale via simple intermediates. Reaction of guanine 1 with acetic anhydride followed by the attachment of the 2-O-acetoxymethyl-1,3-di-O-benzyl glycerol 3 as a side chain, subsequently lead to the production of N2acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl) guanine 6 and N2,acetyl-9-(1,3-dihydroxy-2-propoxy methyl)guanine 7 and finally synthesizing gancyclovir 8. Among many pathways to the synthesis of purine derivatives, our four step procedure results in good yield and is proved to be an economic way of large scale synthesis.
Page(s): 651-654
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(03) [March 2003]

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