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Title: Synthesis of 3-aryl- and 3-aryl-3,4-dihydroisocoumarins
Authors: Ahmad, Hafiz B
Rama, Nasim H
Hussain, Mazhar
Hussain, Muhammad T
Qasim, Malik M
Hameed, Shahid
Malana, Muhammad A
Malik, Abdul
Issue Date: Mar-2003
Publisher: NISCAIR-CSIR, India
Abstract: The condensation of homophthalic acid 6 with the appropriate acid chlorides 7a-c yield the respective isocoumarins 5a-c, which are converted to keto-acids 9a-c by alkaline hydrolysis. The 3,4-dihydroisocoumarins 12a-c are obtained by reduction of the keto-acids 9a-c to hydroxy-acids 11a-c followed by cyclodehydration using acetic anhydride.
Page(s): 611-615
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(03) [March 2003]

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