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Title: Ionic effects on some anticancer drugs from analysis of their metal ion and proton affinities
Authors: Bhattacharyya, P K
Karim, Murshida
Medhi, C
Issue Date: Aug-2007
Publisher: CSIR
Abstract: The proton affinities (PA) and the metal ion affinities (MA) of nitrogen mustards have been investigated to analyze the ionic effect in alkylation reactions. The ion affinities of N4 atomic site of nitrogen mustards are significant, and the proton affinities are more significant than the metal ion affinities. However, Na⁺ affinities are comparatively less than Mg²⁺ affinities. The values of ion affinities have been taken for comparing the ionic effect in alkylation reaction. The magnitudes of PA and MA (Mg²⁺) indirectly show the possibility of inhibitory effect at the intermediate state during aziridinium ion formation of alkylation reaction. So, the presence of H⁺ and Mg²⁺ may change the alkylation rate, since these ions acquire strong affinity for N4 of nitrogen mustards.
Page(s): 1257-1262
ISSN: 0376-4710
Appears in Collections:IJC-A Vol.46A(08) [August 2007]

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