Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21527
Title: Synthesis and antimicrobial screening of N-substituted- 3-chloro-4-dithiocarbamato azetidin-2-ones
Authors: Kumar, Ashok
Sharma, Pratibha
Sharma, Ravi
Mohan, Pankaj
Issue Date: Feb-2003
Publisher: NISCAIR-CSIR, India
Abstract: Some new N-substituted-3-chloro-4-dithiocarbamato azetidin-2-ones have been synthesized and their structures are established on the basis of their elemental, IR and 1H NMR data. All the synthesized compounds have been evaluated for their in-vitro growth inhibitory activity against P. diminuta, B. subtilis, E. coli, S. Aureus, R. rhodochrous. All the compounds show significant antibacterial activity. N-[4' -(N’-4,6-Dimethyl pyrimidinyl) sulphonamoyl amino phenyl]-3-chloro-4-dithiocarbamato azetidin-2-one 2c has been found to be more potent antimicrobial agent against B. subtilis. A perusal of data reveals that molecular refractive index (MR) and vander Waal's volume (Vw) are correlated linearly to the drug activity with correlation coefficient of 0.91 and 0.98, respectively. The synthesized compounds have been subjected to acute toxicity studies to find out LD50 values. The compounds do not show any toxicity up to the dose of 8.5-mg/kg body weights in rats.
Page(s): 416-420
URI: http://hdl.handle.net/123456789/21527
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(02) [February 2003]

Files in This Item:
File Description SizeFormat 
IJCB 42B(2) 416-420.pdf866.58 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.