Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21508
Title: Controlled-release performance of chitosan-polyuronic acid adducts
Authors: Chhatbar, Mahesh U
Meena, Ramavatar
Godiya, Chirag B
Siddhanta, A K
Keywords: Polyuronic acid;Chitosan;Drug release studies;Polymannuronic acid;Polyguluronic acid;X-ray diffraction
Issue Date: 4-Oct-2013
Abstract: Controlled release performance of chitosan-polyuronic acid (polymannuronic and polyguluronic acid) adducts, has been evaluated using five structurally different drugs, i.e., paracetamol (PCT), indomethacine (IND), isoniazid (INH), atenolol (ATN) and pravastatin (PST). The release rates of PCT, INH and ATN, all containing¬† -NH-CO-moieties, show an inverse correlation with the change in pH, i.e., highest at pH 1.2 and lowest at pH 7.4. A reversed trend is noted with IND and PST, having no -NH-CO-moieties; the release rates are highest at pH 7.4 and lowest at pH 1.2. This appears to have a correlation with the structural features of the adducts and the drugs alike, containing -NH-CO-groups, manifesting pH-dependent preferential interactions of -NH-CO-groups through intermolecular hydrogen bonding facilitated at a higher pH. This study presents an array of biopolymer-based materials, which can be harnessed for delivering specific dosage schedules and would be of potential utility in pharmaceutical formulations.
Page(s): 1269-1274
URI: http://hdl.handle.net/123456789/21508
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.52A(10) [October 2013]

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