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Title: Synthesis and biological activity of some new benzophenothiazines
Authors: Pandey, V K
Negi, H S
Joshi, M N
Bajpai, Ms S K
Issue Date: Jan-2003
Publisher: NISCAIR-CSIR, India
Abstract: Condensation of carboxylic acids with thiosemicarbazide in presence of conc. H2SO4 gives 2-amino-5-aralkyl-1,3,4-thiadiazoles 1 which on diazotization afford 5-aralkyl-1,3,4- thiadiazolyl-2-diazonium chlorides 2. Reaction of 2 with cold solution of β-naphthol in dilute NaOH furnishes α-(2-diazo-5-aralkyl-1,3,4-thiadiazolyl)-β-sodionaphthoxides 3 which on acidification with conc. HCl gives α-(2-diazo-5-aralkyl-1,3,4-thiadiazolyl)-β-naphthols 4. Reaction of 4 with p-anisidine gives α-(2-diazo-5-aralkyl-1,3, 4-thiadiazolyl)-β-(p-anisidino) naphthalenes 5. Fusion of 5 with sulphur in presence of iodine results in 1-(2'-diazo-5' -aralkyl-1',3',4' -thiadiazolyl)-6-methoxy benzophenothiazines 6 in yields varying from 48% to 59%. The new compounds 6 have been screened for their antiviral and antifungal activities.
Page(s): 206-210
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.42B(01) [January 2003]

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