Synthesis, characterization and antimicrobial studies of Sb(III) complexes of substituted thioimines

Abstract

Some antimony complexes of a new class of substituted thioimines have been prepared by reacting Ph₃Sb (III) with [1-(2-naphthyl) ethyledene] hydrazinecarbodithioic acid phenyl methyl ester (L¹H), [1-(2-thienyl) ethyledene] hydrazinecarbodithioic acid phenyl methyl ester (L²H), [1-(2-pyridine) ethyledene] hydrazinecarbodithioic acid phenyl methyl ester (L³H) and [1-(2-furanyl)ethyledene] hydrazinecarbodithioic acid phenyl methyl ester (L⁴H), in unimolar and bimolar ratios using thermal as well as microwave method. All the new complexes have been characterized by elemental analyses, molecular weight determinations and spectral studies including electronic, IR, ¹H and ¹³C NMR spectra. The spectral data are consistent with the tetra-coordinated and penta-coordinated environments around Sb(III). The bidentate ligands coordinate through the nitrogen and sulfur atoms. Free ligands and their metal complexes have been screened for their antimicrobial activity on different species of pathogenic fungi and bacteria and their biological activity is discussed briefly.