Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21376
Title: Dual fluorescence and biological evaluation of paracetamol ethers from 4-bromomethylcoumarins
Authors: Shastri, Lokesh A
Manjunath, Ghate D
Kulkarni, Manohar V
Issue Date: Nov-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 A 61 K 31/167
Abstract: Paracetamol 1 has been reacted with 4-bromomethylcoumarins 2 to obtain the corresponding ethers 3 which have been hydrolyzed to the amino ethers 4. Structure of 4 has been confirmed by the chemoselective reaction of 2 with p-aminophenol, which has also been found to yield the thermodynamically controlled products 5 at elevated temperatures. Compounds 3 have been found to exhibit dual fluorescence. IR,1H NMR and mass spectral data have confirmed structures of all the compounds. Biological evaluation has shown that compounds 3e and 3g show good anti-inflammatory and analgesic properties.
Page(s): 2416-2422
URI: http://hdl.handle.net/123456789/21376
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(11) [November 2004]

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