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Title: Synthesis and characterization of 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives containing 2-chloropyridin-5-yl-methyl moiety
Authors: Holla, B Shivarama
Prasanna, C S
Poojary, Boja
Rao, K S
Shridhara, K
Bhat, U Ganesha
Issue Date: Oct-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C07 D 285/12, 271/10
Abstract: Reaction of 2-chloropyridine-5-acetic acid hydrazide 1 with aroyl isothiocyanates 2a-e yields 4-aroyl -1-(2-chloropyridine-5-acetyl)thiosemicarbazides 3a-e. The cyaclization of 3a-e with conc. sulphuric acid and with iodine in the presence of potassium iodide affords 2-chloro-5-(5-aroylamino-1,3,4-thidiazol -2-yl-methyl)pyridines 4a-e and 2-chloro-5-(5-aroylamino-1 ,3,4-oxadiazol-2-yl-methyl) pyridines 5a-e respectively.
Page(s): 2170-2174
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(10) [October 2004]

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