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Title: Mutual prodrugs of 4-biphenylacetic acid and phytophenolics as safer NSAIDs-Synthetic and spectral studies
Authors: Sharma, Pritam Dev
Kaur, Gurbinder
Kansal, Sumeet
Chandiran, Senthil Kumar
Issue Date: Oct-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 C 57/32
Abstract: 4-Biphenylacetic acid (4-BPA), the active metabolite of NSAID fenbufen has been modified using mutual prodrug approach. Number of 4-BPA derivatives have been synthesised as potential mutual prodrugs by the attachment of several phytophenols/alcohol as promoieties through ester linkage, directly as well as through spacers, with the objective of obtaining safer NSAIDs devoid of their ulcerogenic side effects. The structures of these derivatives have been established on the basis of spectral analysis.
Page(s): 2159-2164
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(10) [October 2004]

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