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|Title:||Synthesis and NMR study of the stereochemistry of r(2),c(6)-diaryl-c(3)chloropiperidin-4-ones|
|IPC Code:||Int.Cl.7 C 07 D 295/00|
|Abstract:||r(2),c(6)-Diaryl-c(3)-chloropiperidin-4-ones have been obtained by the epimerization of r(2),c(6)-diaryl-t(3)chloropiperidin-4-ones by treatment with ammonia in DMF. The 1H and 13C NMR spectra of these piperidones were measured in CDCl3 at 360 and 90 MHz respectively and the chemical shifts assigned unambiguously employing one dimensional 1H and 13C and two-dimensional H, H-COSY, C,H-COSY and NOESY NMR spectra. NMR spectroscopic parameters of the epimeric pair of chloropiperidones have been compared and the differences rationalized in terms of stereochemical features.|
|Appears in Collections:||IJC-B Vol.43B(10) [October 2004]|
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