Please use this identifier to cite or link to this item:
Title: Chloramine-T mediated synthesis of 1,8-naphthyridinyl-1,3,4-oxadiazoles
Authors: Mogilaiah, K
Srinivas, K
Sudhakar, G Rama
Issue Date: Sep-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07D 271/10
Abstract: 3-Phenyl-1,8 -naphthyridin-2(1H)-one 1 on reaction with ethyl chloroacetate afford s ethyl (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetate 2, which on treatment with hydrazine hydrate yields (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetic acid hydrazide 3. The acid hydrazide 3 reacts with various aromatic aldehydes to give the corresponding (2-oxo-3 -phenyl-2H[1,8]naphthyridin-1-yl)acetic acid arylidenehydrazides 4. Oxidative cyclization of 4 with chloramine-T furnishes 1-(5-aryl[1,3,4]-oxadiazol-2-ylmethyl)-3-phenyl-1 H-[1 ,8]naphthyridin-2-ones 5. These compounds have been characterized on the basis of elemental analyses, IR, 1H NMR and MS. Compounds 5 have been screened for their antibacterial activity.
Page(s): 2014-2017
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(09) [September 2004]

Files in This Item:
File Description SizeFormat 
IJCB 43B(9) 2014-2017.pdf644.53 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.