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Title: A simple and efficient method for the synthesis of 1,2-benzisoxazoles: A series of its potent acetylcholinesterase inhibitors
Authors: Basappa
Mantelingu, K
Sadashiva, M P
Rangappa, K S
Issue Date: Sep-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C07 D 263/54
Abstract: A simple and efficient method for the synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride is achieved. This reaction involves hydroxylamine sulfate/ KOH mediated, in situ generated oxime formation and its subsequent internal cyclisation followed by alkaline hydrolysis of N-protected ketone in one step. Synthesis of 1,2-benzisoxazole analogues is described and they are found to be potent acetylcholinesterase inhibitors.
Page(s): 1954-1957
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(09) [September 2004]

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