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Title: Synthesis of biologically active N-[coumarin-6-yl]-3-methyl-5-(hydroxy/methyl/4-hydroxy-8-methylcoumarin-3-yl)pyrazoles and [2.3.1]-bicyclo-N-[coumarin-6-yl]-1,2-diazepines
Authors: Choudhari, B P
Mulwad, V V
Issue Date: Jul-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D 231/00, C 07 D 243/00
Abstract: 6-Coumarinylhydrazine hydrochloride 1 on condensation with various active methylene compounds such as ethyl acetoacetate, acetylacetone, 3-(1,3-dioxobutyl)-4-hydroxy-8-methyl-2H-[1]-benzopyran-2-one and 1,3-cyclohexadione separately, yields the corressponding N-[coumarin-6-yl]-5-hydroxy-3-methylpyrazole 3, N-[coumarin-6-yl)-3,5-dimethylpyrazole 4, N-(coumarin-6-yl)-3-methyl-5-(4-hydroxy-8-methylcoumarin-3-yl)pyrazole 5 and [2.3.1)-bicyclo-N-(coumarin-6-yl)-4H-5,6-dihydro-1,2-diazepine 6. The structures of all the compounds have been confirmed on the basis of spectral and analytical data. All the above compounds have been screened for their antimicrobial activity and are found to possess significant antibacterial and antifungal activities.
Page(s): 1544-1547
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(07) [July 2004]

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