Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/21311
Title: Synthesis of anti-inflammatory, analgesic and COX-II inhibitory activities of indolylpyrazolines
Authors: Kumar, Ashok
Archana
Sharma, Shalabh
Malik, Nidhi
Sharma, Preeti
Kaushik, Kavita
Saxena, Kuldeep Kumar
Srivastava, Virendra Kishore
Verma, R S
Sharma, Himansahu
Gupta, S C
Gupta, Vipul
Agarwal, R C
Issue Date: Jul-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D 209/04 // A 61 P 29/00
Abstract: Some l-[N-phenylsulphonyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazolines 7,8 and 1-[N-benzoyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3yl)]-2-pyrazolines 5,6 have been synthesized by the reaction of 3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)-2-pyrazolines 3,4 with benzenesulphonylchloride and benzoyl chloride respectively. The compounds of this series are screened for their anti-inflammatory, analgesic and COX-II inhibitory activities and compared with standard drugs, aspirin and indomethacin. The most active compound of this series is 1-[N-phenylsulphonyl-3 -(2' -phenyl-3'- sulphonyl-5'-methoxyindol -3'-yl)]-2 -pyrazoline 8.
Page(s): 1532-1536
URI: http://hdl.handle.net/123456789/21311
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(07) [July 2004]

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