NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.47A [2008] >
IJC-A Vol.47A(05) [May 2008] >

Title: Synthesis, structure, DNA-binding and photocleavage activity of a binuclear copper(II) complex
Authors: Patra, Ashis K
Gupta, Tarkeshwar
Roy, Sovan
Issue Date: May-2008
Publisher: CSIR
IPC CodeInt.Cl. ⁸ C07F1/08
Abstract: A binuclear copper(II) complex [Cu(L)(NO₃)]₂ (1), where L is a NSO-donor reduced Schiff base ligand derived from salicylaldehyde and 2-mercaptoethylamine, is prepared, structurally characterized as 10.5MeCN by single crystal X-ray diffraction method and its DNA binding and photo-induced DNA cleavage activity studied. Complex 1 has a diphenoxo-bridged binuclear structure with a {Cu₂(μ-OAr)₂} core showing CuNO₃S coordination at each metal centre. The redox active complex displays two quasi-reversible cyclic voltammetric responses at 0.26 V (ΔEp = 390 mV) and at 0.078 V (ΔEp = 375 mV) versus SCE in DMF-0.1 M TBAP at scan rate of 50 mV s⁻¹. The complex exhibits a d-d band at 661 nm in DMF and shows moderate binding propensity to calf thymus DNA. It cleaves supercoiled (SC) DNA in the presence of 3-mercaptopropionic acid as a reducing agent. The complex is active in showing photo-induced cleavage of supercoiled pUC19 DNA in UV light of 365 nm and red light of 633 nm (He-Ne laser). The DNA photocleavage reaction involves formation of singlet oxygen (¹O₂) as the reactive species in a type-II pathway.
Page(s): 643-649
ISSN: 0376-4710
Source:IJC-A Vol.47A(05) [May 2008]

Files in This Item:

File Description SizeFormat
IJCA 47A(5) 643-649.pdf333.54 kBAdobe PDFView/Open
 Current Page Visits: 1051 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 162648 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: