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Title: Synthesis and characterization of some novel 4-formyl pyrazolylthiazoles of potential medicinal interest using Vilsmeier-Haack reaction
Authors: Sharma, Pawan K
Singh, Karan
Dhawan, S N
Singh, S P
Issue Date: Oct-2002
Publisher: NISCAIR-CSIR, India
Abstract: Two series of 4-formyl-1, 3-disubstituted pyrazoles namely 2-[3-(2,4-difluorophenyl)-4-formylpyrazol-l-yl]-6-substituted benzothiazoles (3) and 2-[3-(2,4-difluorophenyl)-4-formylpyrazol-lyl]-4-arylthiazoles (7) have been synthesized for evaluation of their antifungal activity through Vilsmeier-Haack reaction on hydrazones (2, 6) of 2,4-difluoroacetophenone with 2-hydrazino-6-substituted benzothiazoles (2) and 2-hydrazino-4-phenyll substituted phenylthiazoles (6). None of the compounds exhibit any significant antifungal activity.
Page(s): 2071-2075
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.41A(10) [October 2002]

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